APEN exhibits in vivo and in vitro bactericidal activity against some Gram-positive and Gram-negative organisms, in vitro sensitivity does not necessarily imply in vivo efficacy.
Both ampicillin and cloxacillin are acid stable and well absorbed orally, giving peak serum levels two hours after dosing. As there is a linear dose/response in peak serum levels after oral administration of both components, doubling the dose virtually doubles the peak serum levels.
Both components are excreted primarily by the kidneys by glomerular filtration and tubular secretion.
Bile: Bile concentrations of APEN vary from 3 to 48 times the serum concentration, according to the condition of the biliary tract.
Higher APEN serum levels can be achieved in patients with normal renal function by the concurrent administration of a renal blocking agent such as probenecid. In adults, a dose of 500 mg of probenecid four times daily will result in 1,5 - 2 fold increase in APEN serum levels.
|(1)||Best results are obtained if dosages are administered half to one hour prior to meals.|
|(2)||Patients with renal insufficiency may require a reduced dosage.|
|4 May 1993||P1334|