INDICATIONS     CONTRA-INDICATIONS     DOSAGE     SIDE-EFFECTS     PREGNANCY     OVERDOSE     IDENTIFICATION     PATIENT INFORMATION

Logo ANTHRANOL 0,4 Ointment
ANTHRANOL 1,0 Ointment
ANTHRANOL 2,0 Ointment

SCHEDULING STATUS
S3

PROPRIETARY NAME
(and dosage form)

A) ANTHRANOL 0,4 Ointment
B) ANTHRANOL 1,0 Ointment
C) ANTHRANOL 2,0 Ointment

COMPOSITION
  a) Dithranol 0,4% m/m
  b) Dithranol 1,0% m/m
  c) Dithranol 2,0% m/m
PHARMACOLOGICAL CLASSIFICATION
A/13.9.1/Preparations for psoriasis

PHARMACOLOGICAL ACTION
Anti-mitotic

INDICATIONS
For the topical treatment of chronic psoriasis, including psoriasis of the scalp, by the short contact therapy method.

CONTRA-INDICATIONS
Anthranol ointments are contra-indicated for pustular psoriasis and are not suitable for acute psoriasis.

WARNINGS
Preliminary tests should be carried out before treatment to detect any hyper-sensitivity.

Anthranol ointments should not be applied to the face, the inside of the thighs, the genital region or skinfold areas. Should contact with the eyes occur, bathe immediately with water and seek medical advice.

Dithranol is a strong irritant: always wash the hands after using Anthranol ointment. The ointment will cause staining and discolouration to the skin, hair, clothing and bathroom ware. Stains on bathroom ware may be removed by bleach.

Should not be used in patients with renal disease.

DOSAGE AND DIRECTIONS FOR USE.
Treatment should begin with Anthranol 0,4. Clinical response and tolerance will determine the necessity for progression to Anthranol 1,0 and subsequently Anthranol 2,0.

Apply the ointment once daily, sparingly, to the psoriatic plaques. Surrounding normal skin should be protected with white soft paraffin. Leave the ointment on for the required time then remove excess ointment with a paper tissue and wash off the remainder thoroughly.

If Anthranol has been applied to the scalp, the ointment should be removed by shampooing.

The initial daily treatment time with each strength should not exceed 10 minutes. The time may be increased gradually over a period of 7 days to a maximum of 30 minutes. The daily treatment time should not exceed 30 minutes, unless otherwise indicated by your doctor.

Treatment should be continued at the optimum tolerated strength and period of application should depend on patient response.

SIDE EFFECTS AND SPECIAL PRECAUTIONS
See "Warnings" above.

In the event of undue irritation, stop treatment for 2 days and resume on alternate days.

For external use only.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
{none given}

IDENTIFICATION
A yellow, waxy ointment with a very slight odour, free from particles.

PRESENTATION
Tubes of 50g.

STORAGE INSTRUCTIONS
Store in a cool place below 25°C.
Keep out of reach of children.

REGISTRATION NUMBER
W/13.9.1/314
W/13.9.1/315
W/13.9.1/316

APPLICANT
STIEFEL LABORATORIES (SA) (PTY) LTD
20 JULBERT ROAD
BENROSE
2094

DATE OF PUBLICATION
11/89

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