INDICATIONS     CONTRA-INDICATIONS     DOSAGE     SIDE-EFFECTS     PREGNANCY     OVERDOSE     IDENTIFICATION     PATIENT INFORMATION

Logo MINIMS* PILOCARPINE NITRATE 1% Eye Drops
MINIMS* PILOCARPINE NITRATE 2% Eye Drops
MINIMS* PILOCARPINE NITRATE 4% Eye Drops

SCHEDULING STATUS:
Schedule 3

PROPRIETARY NAME:
(and dosage form)

MINIMS* PILOCARPINE NITRATE 1% Eye Drops
MINIMS* PILOCARPINE NITRATE 2% Eye Drops
MINIMS* PILOCARPINE NITRATE 4% Eye Drops

COMPOSITION:
(per dispensing unit of 0,5 mL)
Pilocarpine Nitrate 5 mg
Pilocarpine Nitrate 10 mg
Pilocarpine Nitrate 20 mg

PHARMACOLOGICAL CLASSIFICATION:
A 15.4 Ophthalmic preparation: Other.

PHARMACOLOGICAL ACTION:
Pilocarpine nitrate is a parasympathomimetic drug, which is used to produce tonic constriction of the sphincter pupillae and ciliary muscles, by prolonging and intensifying the action of the parasympathetic nerves.

INDICATIONS:
Pilocarpine nitrate is used to constrict the pupil, to counteract the effect of mydriatic drugs such as atropine and phenylephrine and to decrease the intra-ocular pressure in the treatment of open-angle and closed-angle glaucoma, and detachment of the retina. As a miotic, it is only about half as active as physostigmine, and its action is less complete and of shorter duration.

CONTRA-INDICATIONS:
Pilocarpine nitrate should not be used in patients suffering from bronchial asthma.

DOSAGE AND DIRECTIONS FOR USE:
Adults and children: To be used as directed by the ophthalmologist. Duration of action is 4 to 6 hours.

SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Some discomfort on instillation. Systemic effects, not normally seen on ocular administration are those of parasympathetic stimulation; namely, increased production of saliva, sweat and tears, followed by nausea, profuse vomiting and diarrhoea.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
Not applicable.

CONDITIONS OF REGISTRATION:
Advertising to the professions only.

IDENTIFICATION:
Clear, colourless solution.

PRESENTATION:
Sterile, single dose, disposable eye drops in cartons of 10 units, each containing approximately 0,5 mL.

STORAGE INSTRUCTIONS:
Store in the refrigerator protected from strong light. DO NOT FREEZE.
Keep out of reach of children.

REGISTRATION NUMBERS:
C/15.4/53 Pilocarpine Nitrate 1% Eye Drops
C/15.4/54 Pilocarpine Nitrate 2% Eye Drops
C/15.4/56 Pilocarpine Nitrate 4% Eye Drops

NAME AND BUSINESS ADDRESS OF APPLICANT:
S & N Pharmaceuticals (Pty) Ltd
30 Gillitts Road
Pinetown 3610

DATE OF PUBLICATION OF THIS PACKAGE INSERT:
October 21, 1970

* Trademark
9/67K                SNP 32/2

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