SCORPION VENOM ANTISERUM
Refined Equine Antiscorpion Serum globulins.
T518 (Act 101/1965)
Scorpion Venom Antiserum 5 mL, Cresol 0,3% as Preservative.
Clear, almost colourless or faintly yellow liquid, having a slight odour due to the preservative.
Neutralises the venom of the parabuthus scorpion.
Used for treatment of the sting of the parabuthus scorpion.
Can prevent symptoms and reduce pain if injected with the least possible delay. Stings by other scorpions, and many parabuthus stings, have only a slight effect, and the symptoms produced can often be alleviated without recourse to antivenom. Cold compresses and a local anaesthetic injected at the site of the sting may relieve pain. Urgent serum treatment of stings inflicted by South African scorpions is seldom necessary, unless there is severe shock and a lowered blood pressure.
Should be used with great caution if patient is subject to allergic diseases such as asthma or infantile eczema, or was allergic to any previous antiserum injection.
DOSAGE AND DIRECTIONS FOR USE:
Local symptoms may be relieved by the subcutaneous injection of serum around the site of the sting. For serious parabuthus stings, inject 5 mL intravenously or intramuscularly, and repeat injection after 1 to 2 hours if improvement has not occurred.
SIDE EFFECTS AND SPECIAL PRECAUTIONS:
Reactions are liable to occur after the injection of any serum of animal origin. Anaphylaxis may occur in rare cases, with hypotension, dyspnoea, urticaria, and shock. Anaphylactic reactions should be treated with adrenaline, possibly in association with antihistamine and corticosteroid therapy. Serum sickness may occur 7 to 10 days after the injection of serum of animal origin; symptoms include fever, vomiting, diarrhoea, bronchospasm, and urticaria. Nephritis, myocarditis, neuritis, polyarthritis, and uveitis have been reported as rare complications of serum sickness.
If there is no history of previous serum injection or of allergic reaction, the dose of serum may be given intramuscularly. If the patient is subject to allergic diseases, a trial dose of 0,2 mL (diluted 1:10 if preferred) of the serum should be given subcutaneously; if no general reaction develops within 30 minutes, the main dose may be given intravenously or intramuscularly. The patient must be kept under observation for at least 30 minutes after the injection and adrenaline and a corticosteroid kept in readiness for emergency use.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
Packed singly in ampoules containing 5 mL.
Store at 2° C to 10° C. DO NOT FREEZE. Protect from light.
NAME AND BUSINESS ADDRESS OF APPLICANT:
The South African Institute for Medical Research.
Rietfontein, Edenvale, Transvaal.
P.O. Box 28999, Sandringham, 2131
DATE OF PUBLICATION OF THIS PACKAGE INSERT:
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