INDICATIONS     CONTRA-INDICATIONS     DOSAGE     SIDE-EFFECTS     PREGNANCY     OVERDOSE     IDENTIFICATION     PATIENT INFORMATION
ANADIN® TABLETS

SCHEDULING STATUS:
Not scheduled

PROPRIETARY NAME
(and dosage form):

ANADIN^® TABLETS

COMPOSITION:
Each tablet contains:

	Aspirin	400,0 mg
	Caffeine Anhydrous	22,7 mg

PHARMACOLOGICAL CLASSIFICATION:
A.2.8 Analgesic combinations.

PHARMACOLOGICAL ACTION:
ANADIN TABLETS have analgesic, anti-inflammatory and anti-pyretic action.

INDICATIONS:
ANADIN TABLETS are indicated for the relief of mild to moderate pain and fever.

CONTRA-INDICATIONS:
Patients with peptic ulcers, haemophilia or intolerance (hypersensitivity) to aspirin, severe renal impairment and patients receiving oral anticoagulant therapy.

WARNINGS:
Do not use continuously for more than 10 days without consulting your doctor. The use of tablets during the first and third trimester of pregnancy is not advised except under supervision of a medical doctor.

Aspirin has been implicated in Reye's Syndrome, a rare but serious illness in children and teenagers, with chicken pox and influenza. A doctor should be consulted before Aspirin is used in such patients.

DOSAGE AND DIRECTIONS FOR USE:

Adults:	Two tablets to be taken with water and repeated every four hours if necessary (with a maximum dose of 10 tablets daily).
Children:	Under six years, consult your doctor. Over six years, one quarter to half of the adult dosage (according to age).

SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Dizziness or irritation of the gastric mucosa and resultant dyspepsia, haematemesis, and melaena may occur in some cases. Some persons especially asthmatics, exhibit notable sensitivity to aspirin which may provoke various hypersensitivity reactions which may include skin eruptions, paroxysmal bronchospasm and dyspnoea.

It should be administered with caution to patients with impaired renal function, dyspepsia, anaemia and when the patient is dehydrated.

Aspirin may enhance the activity of coumarin anticoagulants and oral antidiabetic preparations and sulphonamides. Aspirin diminishes the effect of anti-gout preparations such as probenecid and sulphinpyrazone.

Barbiturates and other sedatives may mask the respiratory symptoms of aspirin overdosage and have been reported to enhance its toxicity.
Prolonged use of high doses may lead to anaemia, blood dyscrasias, gastro-intestinal haemorrhage, peptic ulceration and renal papillary necrosis.

The use of aspirin during the first and third trimester of pregnancy is not advised.

Caffeine's side-effects include nausea, headache and insomnia. Caffeine increases gastric secretions and may cause gastric ulcerations.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
"ASPIRIN" COMPONENT:
These include dizziness, tinnitus, sweating, nausea, vomiting, mental confusion, hyperventilation, respiratory alkalosis, metabolic acidosis, ketosis and depression of the Central Nervous System.
In children, serious signs of overdosage may develop rapidly.

"CAFFEINE" COMPONENT:
Overdosage with caffeine may cause symptoms of restlessness, excitement, muscle tremor, tinnitus, scintillating scotoma, tachycardia and extra-systoles.

TREATMENT:
In cases of overdosage, consult a doctor immediately. Treatment is supportive and symptomatic.

IDENTIFICATION:
White compressed tablets with a distinctive arrow on each side.

PRESENTATION:
Available in 2's, 10's, 20's, 50's and 100's.

STORAGE INSTRUCTIONS:
Store in a cool (below 25 °C) dry place. Protect from light. Keep container tightly closed.
KEEP OUT OF REACH OF CHILDREN.

REGISTRATION NUMBER:
B/2.8/835

NAME AND BUSINESS ADDRESS OF APPLICANT:
S.A.D SELF MEDICATION [PTY] LIMITED
(Co. Reg. No. 92/04769/07)
Robbie de Lange Road, Wilsonia, EAST LONDON 5201

DATE OF PUBLICATION OF THIS PACKAGE INSERT:
July 1981

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