||Various forms of dermatitis including urticaria and exfoliative dermatitis, pruritus, paraesthesia, blurring of vision, yellow vision, dizziness, pancreatitis, photosensitivity, postural hypotension, headache, nausea, vomiting or diarrhoea may occur.|
||Anaemia, leucopenia, aplastic anaemia and thrombocytopenia (with purpura) may occur. Agranulocytosis has occurred.|
||Asymptomatic hyperuricaemia can occur and gout may be precipitated.|
||Alterations in glucose tolerance tests with abnormalities of the fasting and 2-hour post-prandial sugar have been observed, and cases of precipitation of diabetes mellitus have been reported.|
||Puresis may lower the serum calcium levels and cases of tetany have been reported.|
||Excessive diuresis may result in dehydration and deduction in blood volume with circulatory collapse and the possibility of vascular thrombosis and embolism, particularly in elderly patients. The excessive loss of potassium in patients receiving cardiac glycosides may precipitate digitalis toxicity. Care should be taken in patients receiving potassium depleting steroids.|
||Electrolyte disturbance Hypokalaemia may be reduced with a potassium-rich diet. If it already exists before the commencement of treatment which is particularly likely to occur in cases of cirrhosis the serum potassium should be restored to normal by potassium supplements and, if necessary, by the administration of sodium and chloride. Because of its strong natriuretic effect, Puresis may cause a decrease in the sodium level, particularly when the oedema is corrected rapidly.|
Electrolyte depletion may manifest itself by weakness, dizziness, lethargy, leg cramps, anorexia, vomiting and/or mental confusion.