DIPHENHYDRAMINE® EXPECTORANT

INDICATIONS CONTRA-INDICATIONS DOSAGE SIDE-EFFECTS PREGNANCY OVERDOSE IDENTIFICATION PATIENT INFORMATION

DIPHENHYDRAMINE® EXPECTORANT

SCHEDULING STATUS:
S2

PROPRIETARY NAME
(and dosage form):

DIPHENHYDRAMINE^® EXPECTORANT

COMPOSITION:
Each 5 mL contains:

	Diphenhydramine Hydrochloride	10,0 mg
	Ammonium Chloride	100,0 mg
	Sodium Citrate	37,50 mg
	Menthol	0,75 mg
	Preservative: Chloroform Spirits in a pleasant-tasting raspberry base.	0,75 mg

PHARMACOLOGICAL CLASSIFICATION:
A 10.1 Antitussives and expectorants

PHARMACOLOGICAL ACTION:
Expectorant and Antihistaminic.

INDICATIONS:
Diphenhydramine Expectorant is a pleasant, raspberry flavoured syrup which is indicated in the control of dry, unproductive cough, and in the alleviation of nasal and bronchial congestion.
Diphenhydramine Expectorant contains Diphenhydramine Hydrochloride, which has central sedative, local anaesthetic, spasmolytic and anti-cholinergic (diminishes upper respiratory tract secretions) properties, in addition to its main antihistaminic actions.
In addition, a relatively high ammonium chloride content provides an effective expectorant action reducing the viscosity of the mucous, which can then act as a demulcent, thereby protecting inflamed and irritated surfaces and inducing a productive cough which is less exhausting and less painful to the patient.

CONTRA-INDICATIONS:
The drug is contra-indicated in epileptics

WARNING:
The use of this medicine may lead to drowsiness and impaired concentration, which may be aggravated by simultaneous intake of alcohol or other central nervous system depressant agents.
Patients undergoing treatment with this drug should not take charge of vehicles, other means of transport, or machinery where loss of attention may lead to accidents.

DOSAGE AND DIRECTIONS FOR USE:

Adults:	Two 5 mL medicine measures.
Children:	12 years:	One and a half 5 mL medicine measures.
	7 years:	One 5 mL medicine measure.
	1 year:	Half a 5 mL medicine measure.

Every three hours, when necessary.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Drowsiness, dizziness and dry mouth may occur.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
Sedation; lack of concentration; lassitude; dizziness; muscular weakness; gastro-intestinal disturbances; convulsions and hyperpyrexia in children; headache; blurred vision; anorexia. Empty the stomach by gastric lavage. The patient should be kept quiet to minimise the excitation which occurs particularly in children and only if control becomes necessary, should Paraldehyde be given by intramuscular injection.
Oxygen should be used for cyanosis and mechanical respiration may be necessary, should respiratory failure occur.
Convulsions are best treated with Paraldehyde, intramuscularly or with a very short-acting barbiturate, such as Thiopentone Sodium 100 mg intravenously.

IDENTIFICATION:
A pleasant raspberry flavoured syrup.

PRESENTATION:
Packs of 100 mL, 500 mL and 2,5 litre.

STORAGE INSTRUCTIONS:
Store below 25°C.
Keep container tightly closed.
Protect from light.
KEEP OUT OF THE REACH OF CHILDREN.

APPLICATION NUMBER:
G586 (Act 101/1965)

NAME AND BUSINESS ADDRESS OF APPLICANT:
South African Druggists Ltd.
7 Fairclough Road
PORT ELIZABETH 6001

DATE OF PUBLICATION

7.8.1974

P160
L.LTD.L.14869/14671