Only physicians experienced in immunosuppressive therapy and management of renal, cardiac and hepatic transplant patients should use ORTHOCLONE.
Serious and occasionally life-threatening systemic, cardio-vascular, and central nervous system reactions have been reported following administration of ORTHOCLONE.
Patients receiving ORTHOCLONE should be managed in facilities equipped and staffed for cardio-pulmonary resuscitation.
|||are sensitive to this product or other products of murine origin.|
|||have antimurine antibody titres > 1:1000.|
|||are in (uncompensated) heart failure or in fluid overload as evidenced by chest X-rays or a greater than three percent weight gain within the week prior to planned ORTHOCLONE administration.|
|||have a history of seizures or are predisposed to seizures.|