Most commonly reported in early cycles of oral contraceptive therapy include breakthrough bleeding, spotting, nausea, vomiting and other gastrointestinal disturbances, and weight change. These frequently decrease with continued use. Other common side-effects include: change in menstrual flow, oedema, chloasma (which may persist post therapy), amenorrhoea, breast changes (tenderness, enlargement and secretion).
In addition to the conditions and disorders discussed above, the following have been reported as adverse reactions in patients using Micro-Novum tablets:
|Neuro-ocular lesions||Cystitis-like syndrome|
|Cervical erosion and secretion||Nervousness|
|Suppression of lactation||Fatigue|
|Changes in libido||Loss of scalp hair|
|Leg cramps||Erythema multiforme|
|Relative pyridoxine deficiency||Erythema nodosum|
The following are some of the medical conditions reported to be influenced by oral contraceptive therapy.
The doctor should be alert to these, carefully monitor the patient and exercise medical judgement to continue or discontinue therapy as appropriate.
Pre-existing uterine fibromyomata may increase in size.
Hypertension may occur in association with the use of oral contraceptives. Regular blood-pressure checks, including a pretreatment level, are advisable.
Prolonged amenorrhoea following the use of oral contraceptives may occur. The incidence is in the order of 1% of users. Caution is advised where oligomenorrhoea or amenorrhoea have occurred in the past. Women with a past history of oligomenorrhoea or secondary amenorrhoea or women with irregular cycles may be more likely to remain anovulatory or to become amenorrhoeic post oral contraceptive therapy.
Mood changes, weight gain, skin pigmentation, vaginal candidiasis, gastro-intestinal irritation and fluid retention may occur.
A decrease in glucose tolerance in a significant number of women may occur.
An increased risk of surgically confirmed gall-bladder disease associated with the use of oral contraceptives has been reported in a retrospective case control study.