INDICATIONS     CONTRA-INDICATIONS     DOSAGE     SIDE-EFFECTS     PREGNANCY     OVERDOSE     IDENTIFICATION     PATIENT INFORMATION

Logo CHLOROQUINE PHOSPHATE INJECTION INTRAMED 200 mg/5 mL

SCHEDULING STATUS:
S4

PROPRIETARY NAME
(and dosage form):

CHLOROQUINE PHOSPHATE INJECTION INTRAMED 200 mg/5 mL

COMPOSITION:
Contains
chloroquine phosphate equivalent to chloroquine base 40 mg/mL.

PHARMACOLOGICAL CLASSIFICATION:
A 20.2.6 –Medicines against protozoa.

PHARMACOLOGICAL ACTION:
Chloroquine has a schizonticidal effect and kills the erythrocytic forms of malaria parasites at all stages of development, but does not affect the sporozoites inoculated by the mosquito or the malaria parasite in human liver cells. It is also amoebicidal. Resistance of malaria parasites to chloroquine have been reported.

INDICATIONS:
Chloroquine injection is used in acute attacks of malaria when the patient is unable to swallow.

CONTRA-INDICATIONS:
Care is needed in administering chloroquine to patients with impaired liver or renal function or with porphyria.

WARNINGS:

DOSAGE AND DIRECTIONS FOR USE:
Adult: 200 to 300 mg chloroquine base by intramuscular or intravenous injection. It should not be given intravenously to children.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Administration must be monitored as cardiovascular collapse with or without cardiac arrhythmia may occur especially after intravenous administration and even after the conventional mode of administration.
Pruritus is a common side-effect; headache and visual and gastrointestinal disturbances occasionally arise, but disappear on discontinuation of treatment. Blood dyscrasias have occasionally been reported.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
Headache, drowsiness, respiratory and cardiovascular depression, arrhythmias, shock, visual disturbances, convulsions, respiratory and cardiac arrest. Overdosage is more likely in children and with intravenous administration. Treatment of overdosage is symptomatic and supportive.

IDENTIFICATION:
A clear solution in amber ampoules.

PRESENTATION:
5 mL ampoules in containers of 10 and 100.

STORAGE INSTRUCTIONS:
Store below 25°C. Protect from light.
Keep out of reach of children.

REGISTRATION NUMBER:
L/20.2.6/343

NAME AND BUSINESS ADDRESS OF APPLICANT:
Intramed (Pty) Ltd
6 Gibaud Road
Port Elizabeth
6001

DATE OF PUBLICATION OF THIS PACKAGE INSERT:
September 1979 12-092/1-95
  Tradepak PE

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