INDICATIONS     CONTRA-INDICATIONS     DOSAGE     SIDE-EFFECTS     PREGNANCY     OVERDOSE     IDENTIFICATION     PATIENT INFORMATION

Logo PROHEP tablets

SCHEDULING STATUS:
Not scheduled

PROPRIETARY NAME
(and dosage form):

PROHEP tablets

COMPOSITION
Per tablet:
Liver hydrolysate 35 mg
Vitamin B12 0,75
Choline bitartrate 50 mg
Cysteine 10 mg
Inositol 12,5 mg

PHARMACOLOGICAL CLASSIFICATION
A 7.4 Lipotropic agents

PHARMACOLOGICAL ACTION
Animal studies have shown that PROHEP protects the liver against a variety of toxins and clinical studies have indicated that it promotes improvement in measurable liver functions.
The liver hydrolysate with essential amino acids contained in PROHEP is obtained from fresh liver, by a special process of hydrolysis. In addition to blood-forming elements including vitamin B12, the hydrolysis of fresh liver cells yields important nucleosides and nucleotides, which act directly on cell metabolism.
Together with the essential amino acids, they protect the liver and stimulate the regeneration of an already affected liver.
PROHEP also promotes local hepatic blood flow and increases diuresis in the presence of ascites.
The effect of PROHEP is further enhanced by the hepatotropic and lipotropic activity of cysteine, choline and inositol.
Choline is accepted as a methyl donor in metabolic processes.
Animal studies indicate that choline (bitartrate) and inositol reduce fatty infiltration of the liver.
Vitamin B12 is an essential factor in the formation of normal red blood cells.
Cysteine, as forerunner of glutathione, has been used in aiding liver functions and treating alcoholism.

INDICATIONS
PROHEP is indicated in liver cirrhosis and chronic hepatitis.
Because of its detoxifying properties, it is also indicated in patients subject to liver damage and liver stress (such as excessive intake of alcohol and fats).

CONTRA-INDICATIONS
None known

DOSAGE AND DIRECTIONS FOR USE
Adults:
Two to four tablets three times a day at or after meals
Four tablets before and after overindulging
Children:
One to three tablets per day at meals

SIDE-EFFECTS AND SPECIAL PRECAUTIONS
A low incidence of mild gastro-intestinal side-effects has been reported

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT
Overdosage could possibly lead to aggravation of the side-effects listed. Treatment consists of withdrawal of the product.

IDENTIFICATION
Brown, coated tablet

PRESENTATION
Tablets: 20, 50, 100 and 200

STORAGE INSTRUCTIONS
Store below 25°C in a dry place.
KEEP OUT OF REACH OF CHILDREN.

REFERENCE NUMBER
H571 (Act 101/1965)

NAME AND BUSINESS ADDRESS OF THE APPLICANT
NORISTAN LIMITED
326 MARKS STREET, WALTLOO, PRETORIA

DATE OF PUBLICATION OF THIS PACKAGE INSERT
3 January 1975

NORISTAN SELFMED
Division of
NORISTAN LIMITED, WALTLOO, PRETORIA

Under licence to Nordmark-Werke GmbH, Hamburg, Germany

        DS 56/015

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