PHARMACOLOGICAL CLASSIFICATION A 16.1 Nasal decongestants
PHARMACOLOGICAL ACTION NASOMIXIN nasal spray is a combination of two vasoconstrictors (phenylephrine and phenylpropanolamine), hydrocortisone, an antibiotic (neomycin sulphate).
The two vasoconstrictors achieve a decongestant action, an effect allowing for the penetration of hydrocortisone, neomycin into the mucosa of the nasal cavities.
The inflammatory reaction in the nasal cavities is suppressed by hydrocortisone, and infection combated by neomycin.
The release-valve ensures a metered quantity of contents to be expelled, and the vehicle ensures uniform distribution of the ingredients to the entire nasal mucosa.
INDICATIONS The treatment of inflammatory (including bacterial), congestive and allergic conditions of the nasal cavities, such as: common cold, allergic rhinitis, vasomotor rhinitis, acute and chronic sinusitis.
CONTRA-INDICATIONS Hypersensitivity to neomycin
DOSAGE AND DIRECTIONS FOR USE Insert the inhalator into the nasal passage and depress the spray-release nozzle, the glass bottle being kept in a vertical position.
Spray one metered dose into the nasal cavity two to four times daily, or according to need.
SIDE-EFFECTS AND SPECIAL PRECAUTIONS Although no side-effects have been reported following the use of NASOMIXIN nasal spray, the possibility of neomycin-sensitivity, resulting from long-term usage, should be borne in mind.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT As for topical corticosteroids and topical sympathomimetics
IDENTIFICATION Clear solution with odour of menthol, in glass bottle providing metered doses
PRESENTATION 15 mL: Glass bottle with metered doses
STORAGE INSTRUCTIONS Store below 25°C. Protect from light.
KEEP OUT OF REACH OF CHILDREN.
REFERENCE NUMBER H1422 (Act 101/1965)
NAME AND BUSINESS ADDRESS OF THE APPLICANT NORISTAN LIMITED 326 MARKS STREET, WALTLOO, PRETORIA
DATE OF PUBLICATION OF THIS PACKAGE INSERT 31 January 1975
NASOMIXIN nasal spray