|A||-||In the oral treatment of:|
|-||all forms of amoebiasis except asymptomatic carrier state|
|-||acute ulcerative gingivitis (Vincentss)|
|B||-||Treatment of infections, in which anaerobic bacteria have been identified or are suspected as pathogens, particularly Bacteroides fragilis and other species of bacteroides and including other species for which metronidazole is bactericidal, such as fusobacteria, clostridia, eubacteria and anaerobic streptococci.|
METRONIDAZOLE has been used successfully for anaerobic infections in the following conditions: pelvic inflammatory disease and postoperative wound infections. Combined therapy is often indicated as there are usually mixed infections.
|C||-||Prevention of postoperative infections due to anaerobic bacteria:|
i) Given before and after gynaecological surgery
ii) Given before and after appendicectomy
iii) Given before and after colonic surgery
|7 TO 10 YEARS||3 TO 7 YEARS||1 TO 3 YEARS|
Where re-infection is likely, in adults the consort should receive a similar course of treatment concurrently.
|1||2g as a single dose|
|7||200 mg three times daily or 400 mg twice daily||100 mg three times daily||100 mg twice daily||50 mg three times daily|
|2||800 mg in the morning and 1,2 g in the evening|
|NON-SPECIFIC VAGINITIS||7||400 mg twice daily|
|OR 1||2 g as a single dose|
a) Invasive intestinal disease in susceptible subjects
|5||800 mg three times daily||400 mg three times daily||200 mg four times daily||200 mg three times daily|
b) Intestinal disease in less susceptible subjects and chronic amoebic hepatitis
|5 to 10||400 mg three times daily||200 mg three times daily||100 mg four times daily||100 mg three times daily|
c) Amoebic liver abscess, also other forms of extra-intestinal amoebiasis
|5||400 mg three times daily||200 mg three times daily||100 mg four times daily||100 mg three times daily|
d) Symptomless cyst passers
|5 to 10||400 to 800 mg three times daily||200 to 400 mg three times daily||100 to 200 mg four times daily||100 to 200 mg three times daily|
A second course of treatment may be necessary for some patients two weeks after the end of the first course
|3||2g once daily||1g once daily||600 to 800 mg once daily||500 mg once daily|
|ACUTE ULCERATIVE GINGIVITIS||3||200 mg three times daily||100 mg three times daily||100 mg twice daily||50 mg three times daily|
|ACUTE PERICORONITIS||3 to 7||200 mg three times daily|
COMPU METRONIDAZOLE TABLETS may be given alone or concurrently with other bacteriologically appropriate antibacterial agents. They should be given for 7 days or longer depending on clinical and bacteriological assessments of the patients condition.
Adults: Initially, 800 mg followed by 400 mg by mouth every 8 hours.
Children: 7,5 mg/kg bodymass by mouth every 8 hours
Adults: Administered in doses similar to those used for the treatment of established infection. 400 mg may be given every 8 hours in the 24 hours before surgery followed postoperatively by intravenous or rectal administration until oral therapy is possible.
Children: as for treatment (a)