INDICATIONS     CONTRA-INDICATIONS     DOSAGE     SIDE-EFFECTS     PREGNANCY     OVERDOSE     IDENTIFICATION     PATIENT INFORMATION

Logo AGIOLAX® Granules

SCHEDULING STATUS:
Unscheduled

PROPRIETARY NAME
(and dosage form):

AGIOLAX® Granules

COMPOSITION:
  100 g of granules contains: 
  Seeds of Plantago ovata 52,0 g
  Ispaghula husk 2,2 g
  Tinnevelly Senna pods 12,4 g
PHARMACOLOGICAL CLASSIFICATION:
A.11.5 (Laxatives)

PHARMACOLOGICAL ACTION:
A characteristic of Agiolax is that its mode of action combines both physical and pharmacological factors. The Plantago seeds are particularly good bulk producers. The bulk thus created acts as a natural stimulant on the stretch receptors in the intestinal wall. The contents of the intestine are given a semi-solid consistency in the higher sections of the large intestine by the indigestible hemicelluloses. Dilation of the bowel by a bulk producing medium alone may often be insufficient; the glycosides from the Senna pods support this stimulus by increasing the responsiveness of the receptors.

INDICATIONS:
Constipation, particularly the chronic forms.
CONTRA-INDICATIONS:
As with all other laxatives : Ileus.

WARNINGS:
This medicine should not be used in the presence of abdominal pain, nausea, or vomiting.

DOSAGE AND DIRECTIONS FOR USE:
1-2 Medicine measures after the evening meal. If necessary the same dose should be taken before breakfast.

Special dosage instructions :

In pregnancy : Because of its natural mode of action Agiolax is particularly suitable for expectant mothers. In most cases 1-2 medicine measures taken every evening will be sufficient.

In obstinate cases : Agiolax may be taken more frequently - up to 2 medicine measures every 6 hours for 1-3 days.

For patients suffering from Haemorrhoids : The normal dose should be taken. The vegetable mucilages of Agiolax soften the motions and ensure pain free evacuation of the bowel.

For prevention : In patients confined to bed (e.g. after operations) and for those of sedentary habits, 1 medicine measure of Agiolax taken once or twice daily will ensure a regular bowel motion.

Note for diabetics : 1 medicine measure of Agiolax contains approximately 0,9 g sucrose.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Bulk laxatives increase flatulence and distension. Agiolax acts gently, does normally not produce any disagreeable side-effects and can safely be taken for long periods. Occasional cramps are rare and usually subside when the dose is reduced.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
Treatment is symptomatic and supportive.

CONDITIONS OF REGISTRATION:
None.

IDENTIFICATION:
Fine grained, medium brown granules, sugar-coated and polished.

PRESENTATION:
Containers of 100 g, 250 g and 1000 g.

STORAGE INSTRUCTIONS:
Store at room temperature (below 30°C). Keep container tightly closed. Keep out of reach of children.

REFERENCE NUMBER:
E988 (Act 101/1965)

NAME AND BUSINESS ADDRESS OF THE APPLICANT:
MADAUS PHARMACEUTICALS (PTY) LTD
2nd Road (cnr. 16th Road)
Randjespark Midrand 1685

DATE OF PUBLICATION OF THIS PACKAGE INSERT:
24/08/72

The granules should not be chewed or dissolved, but should be swallowed with plenty of liquid.

Postal address :

MADAUS PHARMACEUTICALS (PTY) LTD
P O Box 3435
Halfway House
1685

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