Total Daily Dose by Body Surface Area
|Body Surface Area (m2)||No. of UFT (100 mg) capsules per day||No. of Calcium Folinate (15 mg) tablets per day|
|Dose Modification Guideline|
Toxicity may be managed using UFT dose modification scheme described in Table 2. Calcium folinate dose remains unchanged. If the UFT treatment is interrupted, calcium folinate treatment should also be interrupted.
UFT Dose Modification Scheme
|Non-Haematologic Toxicity||Worst CTC* Grade Toxicity||UFT Dose Reductionain mg/m2/day|
|Haematologic Toxicity||0-2c||No change|
|a)||UFT dose reductions expressed as a decrease in mg/m2/day of the preceding dose, based on the worst grade of non-haematologic or haematologic toxicity (granulocyte count or platelet count only). The minimum dose reduction is 1 UFT capsule per day.|
|b)||Therapy withheld until toxicity resolves to < baseline or < grade 1.|
|c)||Therapy withheld until granulocytes > 1500/mm3 and platelets > 100,000/mm3.|
For level 3-4 toxicity, dose reduction maintained for remainder of cycle.