|TAXOL (paclitaxel) should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are readily available.|
Severe hypersensitivity reactions characterised by dyspnoea, flushing, chest pain and tachycardia and hypotension requiring treatment, angioedema, and generalised urticaria have occurred in patients receiving TAXOL. Patients receiving TAXOL should be pre-treated with corticosteroids, promethazine, and H2 antagonists to prevent these reactions. (See "DOSAGE AND ADMINISTRATION" section). Patients who experience severe hypersensitivity reactions to TAXOL should not be rechallenged with the drug.
TAXOL therapy should not be given to patients with baseline neutrophil counts of less than 1,500 cells/mm3. In order to monitor the occurrence of bone marrow suppression, primarily neutropenia, which may be severe and result in infection, it is recommended that frequent peripheral blood cell counts be performed on all patients receiving TAXOL.
The polyoxyethylated castor oil in Taxol can result in phthalate leaching from polyvinyl chloride (PVC) containers, at levels which increase with time and concentration. Consequently, the preparation, storage and administration of diluted TAXOL should be carried out by using non-plasticized PVC-containing equipment.