|Initial and recurrent herpes simplex infections of skin and mucous membranes.||200 mg 5 times daily at 4 hourly intervals for 5 days||In severe initial infection, extend treatment. In immuno-compromised patients, dosage could be increased to 400 mg. The first dose should be administered as early as possible after start of infection.|
|Suppression of recurrent genital herpes simplex infections in immuno-compromised patients||200 mg acyclovir 4 times daily at 6 hourly intervals, or 400 mg 12 hourly.||Some patients may have breakthrough infections on 800 mg daily.|
Interrupt therapy every 6-12 months to observe history of disease.
|Prophylaxis of herpes simplex infections in immuno-compromised patients.||200 mg 4 times daily at 6 hourly intervals||In severely immuno-compromised patients, or impaired absorption from the gut, dosage could be doubled to 400 mg.|
|Treatment of varicella zoster in adolescents (12-18) years||800 mg 4 times a day for 5 days.|
|Treatment of varicella zoster in herpes infections in adults.||800 mg 5 times daily at 4 hourly intervals for 7 days.||Start treatment as early as possible. In severely immuno-compromised patients, or patients with impaired gut absorption, IV dosing should be considered.|
|Management of severely immuno-compromised patients||800 mg 4 times daily at 6 hourly intervals.|
|Dosage in children:
Herpes simplex and prophylaxis of herpes simplex infections in immuno-compromised patients 2 years and older.
|Adult dose.||Orally administered acyclovir in children less than 2 years in age has not yet been fully studied.|
|treatment of varicella zoster (chickenpox) in children||20 mg acyclovir per kg bodymass 4 times daily for 5 days.||Dosage may not exceed 800 mg daily and start treatment as soon as chickenpox rash appear.|
|Dosage in elderly:||Adequate hydration in patients taking high doses must be maintained. Acyclovir clearance in body declines parallel with creatinine clearance.|
|Treatment of prophylaxis of herpes simplex infections in patients with renal impairment.||200 mg every 12 hours if creatinine clearance <10 mL/minute.|
|Treatment of varicella zoster, herpes zoster and immuno-compromised patients with renal impairment.||800 mg twice daily at 12 hourly intervals (creatinine clearance <10 mL/minute).|
800 mg 3 times daily with 8 hourly intervals (creatinine clearance <10-25 mL/minute)