PHARMACOLOGICAL CLASSIFICATION A. 15.4 Ophthalmic preparations. Other.
PHARMACOLOGICAL ACTION PREFRIN Liquifilm is a lubricating decongestant that whitens the eyes and has been found to be beneficial in the relief of minor eye irritation caused by colds, hayfever, dust, smog, hard contact lenses, sun, swimming and wind, in the absence of infection.
INDICATIONS Relief of minor eye irritations.
CONTRA-INDICATIONS Contra-indicated in narrow angle glaucoma. Not intended for use with soft contact lenses.
WARNINGS As the possibility of adverse effects on the corneal permeability and the danger of disruption of the corneal epithelium with prolonged or repeated usage of benzalkonium chloride preserved ophthalmological preparations cannot be excluded, regular ophthalmological examination is required.
Caution should be exercised in the use of benzalkonium chloride preserved topical medication over and extended period in patients with extensive ocular surface disease.
DOSAGE AND DIRECTION S FOR USE One or two drops instilled into each eye. May be repeated at intervals of 3 to 4 hours as required.
SIDE EFFECTS AND SPECIAL PRECAUTIONS Pupillary dilation may occur in some individuals. Should not be used in the presenceof narrow angle glaucoma, and in persons with a known history of hypersensitivity towards any of the ingredients.
KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT. Ocular overdosage may rarely cause systemic sympathomimetic effects (e.g. palpitation, tachycardia, premature ventricular contractions, occipital headache, pallor, trembling, increased perspiration and hypertension). These effects ma be treated with an alpha-adrenoceptor blocking agent followed, if necessary, by a beta-adrenoceptor blocking agent.
IDENTIFICATION A clear colourless solution.
PRESENTATION PREFRIN Liquifilm Sterile Eye Drops are supplied in sterile dropper bottles containing 15 ml solution.
STORAGE INSTRUCTIONS Store below 25°C. Keep bottle closed when not in use. Do not use for more than 30 days after opening. KEEP OUT OF REACH OF CHILDREN.
REGISTRATION NUMBER J/15.4/84
NAME AND BUSINESS ADDRESS OF THE APPLICANT Allergan Pharmaceuticals (Pty) Ltd.
Mount Royal
James Crescent
Halfway House
Johannesburg,
South Africa
DATE OF PUBLICATION OF THIS PACKAGE INSERT 23 December 1976
New addition to this site: December 2006
Source: Pharmaceutical Industry
PREFRIN Liquifilm Sterile Eye Drops