INDICATIONS     CONTRA-INDICATIONS     DOSAGE     SIDE-EFFECTS     PREGNANCY     OVERDOSE     IDENTIFICATION     PATIENT INFORMATION

Logo MERASYN GEL

SCHEDULING STATUS:
NS

PROPRIETARY NAME
(and dosage form):

MERASYN GEL

COMPOSITION:
Each 5 mL:

Aluminium Hydroxide Dried Gel         200 mg
Magnesium Hydroxide         200 mg
Simethicone         20 mg
Methylcellulose         50 mg
Benzyl alcohol 0,3% v/v, Methylparaben 0,09% m/v, Propylparaben 0,012% m/v, Butylparaben 0,012% m/v (added as preservatives).

PHARMACOLOGICAL CLASSIFICATION:
A. 11.4 Antacids.

PHARMACOLOGICAL ACTION:
Both aluminium hydroxide and magnesium hydroxide reduce hyperacidity. Magnesium hydroxide has a rapid and aluminium hydroxide a prolonged antacid action. Peptic activity is inhibited through both antacids by causing elevation of the gastric pH. Aluminium hydroxide has a direct antipeptic action as well as a demulcent effect which helps protect the gastrointestinal mucosa and in this way prevents further irritation or erosion and so permits healing. Aluminium hydroxide has a mild constipating effect and magnesium hydroxide a mild laxative action; because of this balanced effect there is virtually no constipation or diarrhoea. Both antacids are non-systemic and there is virtually no risk of alkalosis developing.
Methycellulose has a demulcent action and helps protect gastrointestinal mucosa. Simethicone aids in the dispersion and inhibits formation of "mucus-surrounded" gas bubbles in the gastrointestinal tract. This anti-foam action is exerted by changing the surface tension of the gas bubbles so that they coalesce. This permits escape of trapped gas, which then can be eliminated through belching or though passing flatus via the rectum. Simethicone has been widely investigated and used. It has a rapid action and is non-toxic. Being physiologically inert, it has no effect on digestion and is not absorbed through the gastrointestinal mucosa. Infants have been shown to tolerate simethicone well.
By dispersing gas bubble with the anti-flatulent, contact with the gastric antacid is facilitated. Coverage of the mucosa by the antacid and demulcent agents is also improved.

INDICATIONS:
Gastric distress resulting from retention of gas and hyperacidity such as may occur in functional dyspepsia. The latter may result from dietary indiscretions, air swallowing, excessive smoking, constipation or altered gastric motor activity.
Gastric hyperactivity, gastritis (including iatrogenic gastritis), heartburn of pregnancy, oesophagitis.
Adjunctively, in peptic ulcer and hiatus hernia.

CONTRA-INDICATIONS:
Known idiosyncrasy to any of the ingredients.

DOSAGE AND DIRECTIONS FOR USE:
One to four medicine measuresful (5-20 mL) one to two hours after meals and at bedtime, or as frequently as the prescribing physician recommends. Shake well before use.

SIDE-EFFECTS AND SPECIAL PRECAUTIONS:
Aluminium may cause nausea, vomiting and constipation. Large doses can cause intestinal obstruction. Excessive or normal doses in patients with low phosphate diets may cause phosphate depletion accompanied by increased resorption and urinary excretion of calcium with the risk of osteomalacia. Osteomalacia, with chronic renal failure on high aluminium dose as a phosphatebinding agent.
Magnesium may cause diarrhoea. Hypermagnesaemia may occur if renal function is impaired. Magnesium hydroxide and other magnesium salts, in the presence of renal insufficiency, may cause central nervous system depression.
Aluminium and magnesium may alter the absorption of other medicines from the gastro-intestinal tract if administered concomitantly.

KNOWN SYMPTOMS OF OVERDOSAGE AND PARTICULARS OF ITS TREATMENT:
There is no experience of overdosage with Merasyn Gel. Treatment is symptomatic and supportive.

IDENTIFICATION:
White viscous gel free from particles and lumps.

PRESENTATION:
200 mL and 350 mL amber glass bottles.

STORAGE INSTRUCTIONS:
Store below 25°C. Keep out of reach of children.
Protect from light.

REGISTRATION NUMBER:
F/11.4/202

NAME AND BUSINESS ADDRESS OF THE APPLICANT:
Adcock Ingram Ltd
Adcock Ingram Park
17 Harrison Avenue
Bryanston
Private Bag X69, Bryanston, 2021

DATE OF PUBLICATION OF THIS PACKAGE INSERT:
14.07.1974

New addition to this site: May 2004
Source: Pharmaceutical Industry

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