Gcina Mhlophe has been writing and performing on stage and screen for the past 21 years. She has written many children's books as well as adult audience poetry and short stories and plays. Her writings are published all over the world and translated into German, French, Italian, Swahili and Japanese. Her work is used extensively in many schools and universities. Gcina produced and performed in the collaboration CD for children with Ladysmith Black Mambazo - released by Music for Little People in America , 1993.

She has written music for the SABCTV series Gcina & Friends where she performed her own stories for television audiences. In 2000 she released an award-winning storytelling CD called Fudukazi's Magic for German audiences. Gcina wrote both the story and music for Fudukazi's Magic which was also produced for video in collaboration with Anant Singh of VideoVision. She has also written both story and music in collaboration with guitarist, Bheki Khoza, for the Animated Tales of the World Series, which featured in Right Angle in the UK as well as the SABC.

In 2001 her CD and book of Nozincwadi Mother of Books was produced as part of her nationwide reading road show to South African rural schools. Her work has received awards from BBC Africa Service for Radio Drama, The Fringe First Award in the Edinburgh Festival, the Josef Jefferson Award in Chicago , and OBBIE in New York . Gcina Mhlophe has received Honorary Doctorates from the London Open University as well as the University of Natal .